Hydrochloric Acid → HCID 24986539, compound

Participants

Reaction Steps

The crude N-[5-(3,5-difluoro-benzenesulfonyl)-1-trityl-1H-indazol-3-yl]-4-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-benzamide was treated with 15 mL of 1,4-dioxane and with 4M hydrochloric acid in 1,4-dioxane (4 mL). The mixture was stirred at room temperature for 2 days then treated with methanol (15 mL) and stirred for additional 3 hours. The solvents were removed under reduced pressure and the residue taken up with ethyl acetate, washed with 10% aqueous ammonium hydroxide, dried over sodium sulfate and evaporated to dryness. The crude was purified by flash chromatography over silica gel eluting with dichloromethane/methanol/7N NH3 in methanol 100:7:1 affording 185 mg of the title compound.

Provenance & Evidence