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DMF Phosphorus oxychloride → 5-(difluoromethoxy)-1H-indole-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | DMF Phosphorus oxychloride | HCID 13765457 | — |
| 反応物 | 5-(difluoromethoxy)-1H-indole | HCID 66737958 | — |
| 反応物 | Sodium chlorite sodium dihydrogen phosphate | HCID 86629097 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 5-(difluoromethoxy)-1H-indole-3-carboxylic acid | HCID 57646514 | — |
反応手順
5-Difluoromethoxyindole (PCT 2007/096395) was formylated in the 3-position using a Vilsmeyer-Haack protocol (phosphorous oxychloride/DMF). The resulting aldehyde was oxidized with sodium chlorite/sodium dihydrogen phosphate in aqueous dioxane. MS (m/e) 227.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08114891B2 |
| 出典データセット | uspto-grants-2012_02 |
| ORD ID | ord-1ab083795a414f71bfc41ecfec8c868f |
| 出典メモ | uspto-grants-2012_02 |