2-methyl-1H-indole-3-carbonyl chloride → Quinuclidin-4-ylmethyl 2-methyl-1H-indole-3-carboxylate

HRID 1641010Notes

Reaction equation

HRID 1641010 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([O:12][CH2:13][C:14]23[CH2:21][CH2:20][N:17]([CH2:18][CH2:19]2)[CH2:16][CH2:15]3)=[O:11])=[CH:2]1.[CH3:22]C1NC2C(C=1C(Cl)=O)=CC=CC=2>>[CH3:22][C:2]1[NH:1][C:9]2[C:4]([C:3]=1[C:10]([O:12][CH2:13][C:14]13[CH2:15][CH2:16][N:17]([CH2:20][CH2:21]1)[CH2:18][CH2:19]3)=[O:11])=[CH:5][CH:6]=[CH:7][CH:8]=2

Participants

3

Reactant 2

HCID 123802742-methyl-1H-indole-3-carbonyl chlorideHCID 25234267(Quinuclidin-4-yl)methyl 1H-indole-3-carboxylate

Product 1

HCID 25234345Quinuclidin-4-ylmethyl 2-methyl-1H-indole-3-carboxylate

Procedure

Quinuclidin-4-ylmethyl 2-methyl-1H-indole-3-carboxylate was prepared in a similar manner to (Quinuclidin-4-yl)methyl 1H-indole-3-carboxylate, substituting 2-methyl-1H-indole-3-carbonyl chloride as the electrophile.

Sources & evidence

ORD record
ord-8bfc973b778d4fd0a48279131c8d1674
Source dataset
uspto-grants-2012_02
Patent number
US08114891B2

Reaction notes

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