1H-Indazole-3-carbonyl chloride → Quinuclidin-4-ylmethyl 1H-indazole-3-carboxylate

HRID 1641011Notes

Reaction equation

HRID 1641011 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([O:12][CH2:13][C:14]23[CH2:21][CH2:20][N:17]([CH2:18][CH2:19]2)[CH2:16][CH2:15]3)=[O:11])=C1.[NH:22]1C2C(=CC=CC=2)C(C(Cl)=O)=N1>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([O:12][CH2:13][C:14]23[CH2:21][CH2:20][N:17]([CH2:18][CH2:19]2)[CH2:16][CH2:15]3)=[O:11])=[N:22]1

Participants

3

Reactant 2

HCID 231899901H-Indazole-3-carbonyl chlorideHCID 25234267(Quinuclidin-4-yl)methyl 1H-indole-3-carboxylate

Product 1

HCID 25234348Quinuclidin-4-ylmethyl 1H-indazole-3-carboxylate

Procedure

Quinuclidin-4-ylmethyl 1H-indazole-3-carboxylate was prepared in a similar manner to (Quinuclidin-4-yl)methyl 1H-indole-3-carboxylate, substituting 1H-indazole-3-carbonyl chloride as the electrophile.

Sources & evidence

ORD record
ord-9e7e139941414664ad0f005f38a74be4
Source dataset
uspto-grants-2012_02
Patent number
US08114891B2

Reaction notes

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