6-Methoxy-1H-indole-3-carboxylic acid → Quinuclidin-4-ylmethyl 6-methoxy-1H-indole-3-carboxylate

HRID 1641018Notes

Reaction equation

HRID 1641018 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:12]([OH:14])=[O:13])=[CH:8][NH:9]2)=[CH:5][CH:4]=1.N1C2C(=CC=CC=2)C(C(O[CH2:27][C:28]23[CH2:35][CH2:34][N:31]([CH2:32][CH2:33]2)[CH2:30][CH2:29]3)=O)=C1>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:12]([O:14][CH2:27][C:28]34[CH2:35][CH2:34][N:31]([CH2:32][CH2:33]3)[CH2:30][CH2:29]4)=[O:13])=[CH:8][NH:9]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 177509566-Methoxy-1H-indole-3-carboxylic acidHCID 25234267(Quinuclidin-4-yl)methyl 1H-indole-3-carboxylate

Product 1

HCID 25234350Quinuclidin-4-ylmethyl 6-methoxy-1H-indole-3-carboxylate

Procedure

Quinuclidin-4-ylmethyl 6-methoxy-1H-indole-3-carboxylate was prepared starting from 6-methoxyindole-3-carboxylic acid (synthesized as described in J. Med. Chem. 51, 1849 (2008)) following the procedure of (Quinuclidin-4-yl)methyl 1H-indole-3-carboxylate. MS (m/e): 314.

Sources & evidence

ORD record
ord-3e79e636c0c749bc90645b6986c7e982
Source dataset
uspto-grants-2012_02
Patent number
US08114891B2

Reaction notes

Loading…