1,4-Dioxa-8-azaspiro(4.5)decane → HCID 59553409, compound

HRID 1641121Notes

Reaction equation

Cl[C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][N:29]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[CH:10][CH:9]=1)=[O:6].[O:30]1[C:34]2([CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[O:33][CH2:32][CH2:31]1>>[O:30]1[C:34]2([CH2:39][CH2:38][N:37]([C:2]3[CH:3]=[C:4]([CH:27]=[CH:28][N:29]=3)[C:5]([NH:7][C:8]3[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[C:11]([O:18][CH2:19][CH2:20][N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[CH:10][CH:9]=3)=[O:6])[CH2:36][CH2:35]2)[O:33][CH2:32][CH2:31]1

Participants

Reactant 2

HCID 674351,4-Dioxa-8-azaspiro(4.5)decane

HCID 59553212HCID 59553212, compound

Product 1

HCID 59553409HCID 59553409, compound

Procedure

Compound is formed by reacting 2-chloro-N-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-isonicotinamide and 1,4-dioxa-8-aza-spiro[4.5]decane under conditions described in general procedure A. 1H NMR (300 MHz, DMSO-d6) δ 10.29 (s, 1H), 8.29 (d, 1H), 8.20 (m, 1H), 7.88 (m, 1H), 7.59 (m, 2H), 7.42 (d, 2H), 7.19 (d, 1H), 7.01 (d, 1H), 4.31 (t, 2H), 3.95 (s, 4H), 3.75 (m, 4H), 3.61 (m, 4H), 2.88 (t, 2H), 2.60 (m, 4H), 2.66 (m, 4H). MS: 519.3 (M+1).

Workup

customCompound is formed

Sources & evidence

ORD record: ord-051411afd775404ab95b40a90dad414b
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08114873B2

Reaction notes

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