1-Acetylpiperazine → HCID 59553209, compound

HRID 1641126Notes

Reaction equation

Cl[C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][N:29]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[CH:10][CH:9]=1)=[O:6].[C:30]([N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)(=[O:32])[CH3:31]>>[C:30]([N:33]1[CH2:38][CH2:37][N:36]([C:2]2[CH:3]=[C:4]([CH:27]=[CH:28][N:29]=2)[C:5]([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([O:18][CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)=[CH:10][CH:9]=2)=[O:6])[CH2:35][CH2:34]1)(=[O:32])[CH3:31]

Participants

Reactant 2

HCID 837951-Acetylpiperazine

HCID 59553212HCID 59553212, compound

Product 1

HCID 59553209HCID 59553209, compound

Procedure

Compound is formed by reacting 2-chloro-N-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-isonicotinamide and 4-acetylpiperazine under conditions described in general procedure A. 1H NMR (300 MHz, DMSO-d6) δ 10.38 (s, 1H), 8.32 (d, 1H, J=5.4), 8.20 (m, 1H), 7.84 (m, 1H), 7.58 (m, 2H), 7.46 (d, 2H), 7.23 (d, 1H, J=5.4), 7.05 (d, 1H, J=8.1), 4.31 (t, 2H), 3.58 (m, 12H), 2.88 (t, 2H), 2.57 (t, 4H), 2.06 (s, 3H). MS: 504.2 (M+1).

Workup

customCompound is formed

Sources & evidence

ORD record: ord-87603d2c83e2477dab040e94c7e0832a
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08114873B2

Reaction notes

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