N-methylpropyn-2-ylamine → 3-Fluoro-N-[4-({2-[methyl(prop-2-yn-1-yl)amino]pyrimidin-4-yl}oxy)-1-naphthyl]-5-morpholin-4-ylbenzamide

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Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and N-methylprop-2-ynylamine according to conditions described in general procedure C. Mp: 97-98° C.; 1H NMR (400 MHz, DMSO-d6) δ 2.88 (s, 3H), 3.26-3.33 (m, 5H), 3.77 (t, J=4.8 Hz, 4H), 4.24 (s, 2H), 6.32 (d, J=5.5 Hz, 1H), 7.06 (d, J=14.3 Hz, 1H), 7.26 (d, J=8.8 Hz, 1H), 7.45-7.64 (m, 5H), 7.85-7.87 (m, 1H), 8.01 (d, J=8.0 Hz, 1H), 8.32 (d, J=5.5 Hz, 1H), 10.49 (s, 1H).

Provenance & Evidence