反应详情

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and (2,2-dimethoxy-ethyl)-methylamine according to conditions described in general procedure C. Mp: 92-94° C.; 1H NMR (400 MHz, DMSO-d6) δ 2.84-3.6 (m, 11H), 3.28 (m, 4H), 3.77 (m, 4H), 4.5 (s, 1H), 6.26-6.24 (m, 1H), 7.04 (d, J=12.0 Hz, 1H), 7.26 (d, J=9.1 Hz, 1H), 7.47-7.65 (m, 5H), 7.82 (m, 1H), 7.99-8.01 (m, 1H), 8.29 (m, 1H), 10.45 (s, 1H).