1-Aminocyclopentanemethanol → HCID 59553120, compound

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Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and (1-amino-cyclopentyl)-methanol according to conditions described in general procedure C. Mp: 115-117° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.16-1.50 (m, 8H), 3.00-3.34 (m, 2H), 3.27 (m, 4H), 3.77 (m, 4H), 6.30 (d, J=5.5 Hz, 1 H), 6.65 (s, 1 H), 7.05 (d, J=12.1 Hz, 1 H), 7.27 (d, J=8.8 Hz, 1H), 7.39 (d, J=8.0 Hz, 1H), 7.49 (s, 1H), 7.56-7.61 (m, 3H), 7.82 (d, J=6.6 Hz, 1 H), 8.00 (d, J=8.4 Hz, 1 H), 8.20 (d, J=5.5 Hz, 1 H), 10.46 (s, 1 H).

Provenance & Evidence