3-(Dimethylamino)pyrrolidine → HCID 59553371, compound

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Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and dimethyl-pyrrolidin-3-yl-amine according to conditions described in general procedure C. Mp: 106-108° C.; 1H NMR (400 MHz, DMSO-d6) δ 2.07-2.17 (m, 10H), 2.45-3.15 (m, 3 H), 3.27 (t, J=4.4 Hz, 4 H), 3.77 (t, J=5.1 Hz, 4H), 6.15 (m, 1 H), 7.05 (d, J=12.1 Hz, 1 H), 7.27 (d, J=9.5 Hz, 1 H), 7.42-7.62 (m, 5 H), 7.85-7.87 (m, 1 H), 8.00 (d, J=7.7 Hz, 1 H), 8.23 (d, J=5.5 Hz, 1 H), 10.47 (s, 1 H).

Provenance & Evidence