Cyclopropylamine → HCID 59553185, compound

Participants

Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and cyclopropylamine according to conditions described in general procedure C. Mp: 118-120° C.; 1H NMR (400 MHz, CDCl3) δ 0.42-0.49(m, 2 H), 0.70(d, J=5.6 Hz, 2 H), 2.65(s, 1 H), 3.25(t, J=4.0 Hz, 4 H), 3.86(t, J=4.8 Hz, 4H), 5.25(s, 1 H), 6.15(d, J=4.8 Hz, 1 H), 6.78(d, J=11.6 Hz, 1 H), 7.06(d, J=8.4 Hz, 2 H), 7.26-7.31(m, 2 H), 7.49-7.57(m, 2 H), 7.89(d, J=8.0 Hz, 1H), 7.96(d, J=8.0 Hz, 1 H), 8.15(s, 1 H), 8.20(d, J=4.4 Hz, 1 H).

Provenance & Evidence