Azetidine → HCID 59553131, compound

Participants

Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and azetidine according to conditions described in general procedure C. Mp: 196-197° C.; 1H NMR (400 MHz, DMSO-d6) δ 2.17-2.25(m, 2 H), 3.23-3.30(m, 6 H), 3.75-3.78(m, 4 H), 3.87(s, 1 H), 6.14(d, J=5.5 Hz, 1 H), 7.03-7.06(m, 1 H), 7.25(d, J=8.8 Hz, 1 H), 7.40-7.63(m, 5 H), 7.84-7.86 (m, 1 H), 7.99-8.01(m, 1 H), 8.22(d, J=5.5 Hz, 1 H), 10.47(s, 1 H).

Provenance & Evidence