(3R)-(+)-3-(Dimethylamino)pyrrolidine → HCID 59553470, compound

Participants

Reaction Steps

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and (R)—N,N-dimethylpyrrolidin-3-amine according to conditions described in general procedure C. Mp: 93-94° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.58 (s, 6 H), 1.60-2.00 (m, 2 H), 2.16 (s, 6H), 2.64 (m, 1 H), 2.90-3.70 (m, 4 H), 3.27-3.28 (m, 4 H), 6.06-6.17 (bd, 1 H), 6.94-6.98 (m, 1H), 7.14 (d, J=8.8 Hz, 1 H), 7.43 (d, J=8.0 Hz, 1 H), 7.46 (s, 1 H), 7.50-7.64 (m, 3 H), 7.82-7.84 (m, 1 H), 7.96-7.98 (m, 1 H), 8.22 (d, J=5.5 Hz, 1 H), 10.43 (s, 1 H).

Provenance & Evidence