Cyanamide → HCID 59553320, compound

HRID 1641195Notes

Reaction equation

HRID 1641195 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[N:38]#[C:39][NH2:40]>>[C:39]([NH:40][C:21]1[N:20]=[C:19]([O:18][C:11]2[C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:8]([NH:7][C:5](=[O:6])[C:4]3[CH:29]=[C:30]([N:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)[CH:31]=[C:2]([F:1])[CH:3]=3)=[CH:9][CH:10]=2)[CH:24]=[CH:23][N:22]=1)#[N:38]

Participants

3

Reactant 2

HCID 9864CyanamideHCID 667379693-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide

Product 1

HCID 59553320HCID 59553320, compound

Procedure

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and cyanamide according to conditions described in general procedure C. Mp: 160-162° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.58 (s, 6 H), 3.27-3.29 (m, 4 H), 6.32 (d, J=5.1 Hz, 1 H), 6.95 (d, J=12.4, 1 H), 7.15 (d, J=9.1 Hz, 1 H), 7.42-7.45 (m, 2 H), 7.55-7.62 (m, 3 H), 7.83 (d, J=8.8 Hz, 1 H), 7.97 (d, J=8.0 Hz, 1 H), 8.13 (d, J=5.8 Hz, 1 H), 10.44 (s, 1 H).

Sources & evidence

ORD record
ord-bf9aa3536a604287938de1bbf90264ae
Source dataset
uspto-grants-2012_02
Patent number
US08114873B2

Reaction notes

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