1,4-Dioxa-8-azaspiro(4.5)decane → HCID 59553250, compound

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Reaction Steps

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and 1,4-dioxa-8-aza-spiro[4.5]decane according to conditions described in general procedure C. Mp: 195-196° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.46-1.59 (s, 10 H), 3.27-3.31 (m, 4 H), 3.56 (s, 4 H), 3.84 (s, 4 H), 6.20-6.22 (m, 1 H), 6.95 (d, J=12.8, 1 H), 7.15 (d, J=9.1 Hz, 1 H), 7.40-7.42 (m, 1 H), 7.45 (s, 1 H), 7.55-7.60 (m, 3 H), 7.83 (d, J=7.7 Hz, 1 H), 7.97 (d, J=8.0 Hz, 1H), 8.25-8.27 (m, 1 H), 10.43 (s, 1 H).

Provenance & Evidence