4-Methylcyclohexylamine → HCID 59553116, compound

HRID 1641200Notes

Reaction equation

HRID 1641200 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[CH3:38][CH:39]1[CH2:44][CH2:43][CH:42]([NH2:45])[CH2:41][CH2:40]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([NH:45][CH:42]3[CH2:43][CH2:44][CH:39]([CH3:38])[CH2:40][CH2:41]3)[N:20]=2)=[CH:10][CH:9]=1)=[O:6]

Participants

3

Reactant 2

HCID 806044-MethylcyclohexylamineHCID 667379693-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide

Product 1

HCID 59553116HCID 59553116, compound

Procedure

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and 4-methylcyclohexylamine according to conditions described in general procedure C. Mp: 101-102° C.; 1H NMR (400 MHz, DMSO-d6) δ 0.82 (d, J=6.6 Hz, 3 H), 0.86-1.59 (m, 15 H), 3.27-3.36 (m, 5 H), 6.27 (bs, 1 H), 6.96 (d, J=12.8, 2 H), 7.15 (d, J=8.4 Hz,1 H), 7.36-7.39 (m, 1H), 7.43 (s, 1 H), 7.54-7.60 (m, 3 H), 7.79-7.83 (m, 1 H), 7.96 (d, J=7.3 Hz, 1 H), 8.18 (s, 1H), 10.40 (s, 1 H).

Sources & evidence

ORD record
ord-9eeba92ac4404b8182b85934aa51ebf7
Source dataset
uspto-grants-2012_02
Patent number
US08114873B2

Reaction notes

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