Morpholine → HCID 59553356, compound

Participants

Reaction Steps

Compound is prepared from 3-fluoro-5-(4-methylpiperidin-1-yl)-N-(4-{[2-(methylthio)pyrimidin-4-yl]oxy}-1-naphthyl)benzamide (0.1 g, 0.2 mmol) and morpholine (10 mmol) according to conditions described in Step 4 of Example 3 and general procedure C. A pink solid is produced (15 mg). Mp: 88-89° C.; 1H NMR (300 MHz, CDCl3) δ 0.98(d, J=6.6 Hz, 3H), 1.25-1.38(m, 3H), 1.75 (d, J=12.6 Hz, 2H), 2.78-2.86(m, 2H), 3.64(s, 9H), 3.77(d, J=12 Hz, 1H), 6.07(d, J=5.7 Hz, 1H), 6.77(d, J=12 Hz, 1H), 6.98(d, J=7.8 Hz, 1H), 2.30-7.33(m, 2H), 7.49-7.60(m, 2H), 7.89-7.99(m, 3H), 8.13(s, 1H), 8.18(d, J=5.7 Hz, 1H); MS 542 (M+1).

Provenance & Evidence