反应详情

Compound is prepared from tert-butyl(4-hydroxy-1-naphthyl)carbamate, 3-fluoro-5-piperidin-1-yl-benzoic acid and 1-(2-hydroxy-ethyl)-pyrrolidin-2-one according to conditions described in general procedure D. A pink solid is produced (38 mg). Mp: 69-71° C.; 1H NMR (300 MHz, DMSO-d6) δ 1.58(s, 6H), 3.28(s, 4H), 5.42(s, 2H), 6.95(d, J=8.4 Hz, 1H), 7.06(d, J =8.1 Hz, 1H), 7.15(d, J=6.9 Hz, 1H), 7.44(s, 1H), 7.55-7.60(m, 4H), 7.85-7.92(m, 1H), 8.30-8.38(m, 1H), 8.60-8.63(m, 1H), 10.26(s, 1H); MS 456 (M+1).

1. customA pink solid is produced (38 mg)