3-Furanmethanol → 3-Fluoro-N-[4-(3-furylmethoxy)-1-naphthyl]-5-piperidin-1-ylbenzamide

Participants

Reaction Steps

Compound is prepared from tert-butyl(4-hydroxy-1-naphthyl)carbamate, 3-fluoro-5-piperidin-1-yl-benzoic acid and furan-3-yl-methanol according to conditions described in general procedure D. A pink solid is produced (12 mg). Mp: 152-153° C.; 1H NMR (300 MHz, CDCl3) δ 1.63-1.69(m, 6H), 3.20-3.27(m, 2H), 5.13(s, 2H), 6.58(s, 1H), 6.75(d, J=12.6 Hz, 1H), 6.89(d, J=8.4 Hz, 1H), 6.98(d, J=9.0 Hz, 1H), 7.30(s, 1H), 7.47-7.59(m, 4H), 7.12(d, J=8.1 Hz, 1H), 7.83(d, J=8.4 Hz, 1H), 7.95(s, 1H), 8.32(d, J=8.1 Hz, 1H); MS 445 (M+1).

Provenance & Evidence