3-(1H-pyrrol-1-yl)benzoic acid → HCID 59553329, compound

HRID 1641239Notes

Reaction equation

HRID 1641239 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=2)[C:9]([OH:11])=O)[CH:5]=[CH:4][CH:3]=[CH:2]1.[N:15]1([CH2:21][CH2:22][O:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:27]([NH2:34])=[CH:26][CH:25]=2)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[N:15]1([CH2:21][CH2:22][O:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:27]([NH:34][C:9](=[O:11])[C:8]3[CH:12]=[CH:13][CH:14]=[C:6]([N:1]4[CH:2]=[CH:3][CH:4]=[CH:5]4)[CH:7]=3)=[CH:26][CH:25]=2)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 7365373-(1H-pyrrol-1-yl)benzoic acidHCID 110439124-(2-Morpholinoethoxy)naphthalen-1-amine

Product 1

HCID 59553329HCID 59553329, compound

Procedure

Compound is prepared from 3-pyrrol-1-yl-benzoic acid and 4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-ylamine according to conditions described in general procedure G. (96 mg) (40%). Mp: 142-143° C. 1H NMR (300 MHz, DMSO-d6) δ 10.38 (s, 1H), 8.25 (m, 2H), 7.90 (m, 2H), 7.83 (d, J=8.1, 1H), 7.66-7.47 (m, 6H), 7.06 (d, J=8.4 Hz, 1H), 6.32 (brs, 2H), 4.33 (t, J=5.4, 2H), 3.62 (brt, 4H), 2.93 (brs, 2H), 2.62 (brs, 4H). MS: 442 (M+1).

Sources & evidence

ORD record
ord-30a9f1b3e6394ffd8f670a352f5c1eb7
Source dataset
uspto-grants-2012_02
Patent number
US08114873B2

Reaction notes

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