HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-Chloro-6-morpholinopyrimidine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 2-chloro-6-morpholin-4-ylpyrimidine-4-carboxylate | HCID 4356884 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Chloro-6-morpholinopyrimidine-4-carboxylic acid | HCID 18422079 | 99.1% |
Reaction Steps
A suspension of methyl 2-chloro-6-morpholin-4-ylpyrimidine-4-carboxylate (0.30 g, 1.16 mmol) in a mixture of THF:H2O:MeOH (12 ml, 4:1:1) is stirred at room temperature for 24 hrs with lithium hydroxide (28 mg, 1.0 eq). The mixture is then evaporated to dryness to give 2-chloro-6-morpholin-4-ylpyrimidine-4-carboxylic acid as a solid (280 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08114873B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-12a728ef9d6a489ebdb2bf3481648fa1 |
| Source note | uspto-grants-2012_02 |