HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(2-Methylsulfanylpyrimidin-4-yloxy)-naphthalen-1-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | t-Butyl(4-{[2-(methylthio)pyrimidin-4-yl]oxy}-1-naphthyl)carbamate | HCID 59553280 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(2-Methylsulfanylpyrimidin-4-yloxy)-naphthalen-1-ylamine | HCID 59553385 | 151.7% |
Reaction Steps
To a stirred solution of [4-(2-methylsulfanylpyrimidin-4-yloxy)-naphthalen-1-yl]-carbamic acid tert-butyl ester (1.375 g, 3.6 mmol) in anhydrous dioxane (10 ml) at room temperature is added 4M HCl in dioxane (12 ml, 48 mmol). After 1 day the mixture is evaporated to dryness to give 4-(2-methylsulfanylpyrimidin-4-yloxy)-naphthalen-1-ylamine as a light purple powder (1.547 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08114873B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-ea41be0eb86447c09b468ef8933d74cb |
| Source note | uspto-grants-2012_02 |