HCID 178517968, compound → HCID 178507564, compound

Participants

Reaction Steps

A 100 mL EtOH solution of 1.0 g (2.1 mmol) 8-(3-nitrobenzyl)-4-(cyclohexylamino)-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one (example 104) and 0.57 g (2.5 mmol) SnCl2 dihydrate was heated to reflux and allowed to stir overnight. HPLC/MS showed complete conversion so the reaction mixture was filtered through celite washed with EtOH then the filtrate was concentrated. The remaining oil was partitioned between 3N NaOH and EtOAc. A thick white precipitate formed in the aqueous layer. The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated to pure product.

Provenance & Evidence