Acetone → HCID 178456740, compound

HRID 1641315Notes

Reaction equation

[NH2:1][C:2]1[CH:33]=[CH:32][CH:31]=[CH:30][C:3]=1[CH2:4][N:5]1[CH2:29][CH2:28][C:8]2([N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=3)[C:11](=[O:20])[N:10]=[C:9]2[NH:21][CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[CH2:7][CH2:6]1.[CH3:34][C:35]([CH3:37])=O>>[CH:22]1([NH:21][C:9]2[C:8]3([CH2:28][CH2:29][N:5]([CH2:4][C:3]4[CH:30]=[CH:31][CH:32]=[CH:33][C:2]=4[NH:1][CH:35]([CH3:37])[CH3:34])[CH2:6][CH2:7]3)[N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=3)[C:11](=[O:20])[N:10]=2)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1

Participants

Reactant 2

HCID 180Acetone

HCID 178507494HCID 178507494, compound

Product 1

HCID 178456740HCID 178456740, compound

Procedure

Produced using Method Z substituting acetone for the aldehyde and 8-(2-aminobenzyl)-4-(cyclohexylamino)-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one (example 80) for the substrate. MS 492.4

Workup

customProduced

Sources & evidence

ORD record: ord-0114d83abe34402e83f192ce857517ae
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08114887B2

Reaction notes

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