Isobutylamine → HCID 178448891, compound

HRID 1641323Notes

Reaction equation

HRID 1641323 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]3([CH2:17][CH2:16][N:15]([CH2:18][C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH:26]([CH3:28])[CH3:27])[CH:20]=4)[CH2:14][CH2:13]3)[C:11](=S)[NH:10][C:9]2=[O:30])[CH:5]=[CH:6][CH:7]=1.[CH2:31]([NH2:35])[CH:32]([CH3:34])[CH3:33]>CS(C)=O>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]3([CH2:17][CH2:16][N:15]([CH2:18][C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH:26]([CH3:28])[CH3:27])[CH:20]=4)[CH2:14][CH2:13]3)[C:11]([NH:35][CH2:31][CH:32]([CH3:34])[CH3:33])=[N:10][C:9]2=[O:30])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6558IsobutylamineHCID 58949994HCID 58949994, compound

Product 1

HCID 178448891HCID 178448891, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
110 °C

Procedure

To a solution of 1-(3-Fluoro-phenyl)-8-(3-isopropoxy-benzyl)-4-thioxo-1,3,8-triaza-spiro[4.5]decan-2-one SNS-1 (21.4 mg, 0.05 mmol) in DMSO (1 mL) was added isobutyl amine (36.5 mg, 0.5 mmol). The reaction mixture was heated at 110° C. for 12 hr. The crude was purified by preparative HPLC to provide (14-8).

Workup

  1. customThe crude was purified by preparative HPLC

Sources & evidence

ORD record
ord-5d81e846a8ff4819a2722a9ba4fb0d5d
Source dataset
uspto-grants-2012_02
Patent number
US08114887B2

Reaction notes

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