1-(4-(Methylsulfonyl)phenyl)piperazine → HCID 59708466, compound

HRID 1641335Notes

Reaction equation

HRID 1641335 reaction equation
F[C:2]([F:7])(F)[C:3](O)=O.Cl[C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[N:22]=[C:23]([NH:31][C@H:32]([CH:35](C)[CH3:36])[CH2:33]N)[C:24]4[S:29](=[O:30])[CH2:28][CH2:27][C:25]=4[N:26]=3)[CH2:17][CH2:16]2)=[CH:11][CH:10]=1.[CH3:38][S:39](C1C=CC(N2CCNCC2)=CC=1)(=[O:41])=[O:40]>>[F:7][C:2]1[CH:33]=[C:32]([NH:31][C:23]2[C:24]3[S:29](=[O:30])[CH2:28][CH2:27][C:25]=3[N:26]=[C:21]([N:18]3[CH2:19][CH2:20][N:15]([C:12]4[CH:13]=[CH:14][C:9]([S:39]([CH3:38])(=[O:41])=[O:40])=[CH:10][CH:11]=4)[CH2:16][CH2:17]3)[N:22]=2)[CH:35]=[CH:36][CH:3]=1

Participants

3

Reactant 2

HCID 7359041-(4-(Methylsulfonyl)phenyl)piperazineHCID 67491837HCID 67491837, compound

Product 1

HCID 59708466HCID 59708466, compound

Procedure

Starting from 2-chloro-5-oxo-6,7-dihydro-5H-5λ4-thieno[3,2-d]pyrimidin-4-yl)-(3-fluoro-phenyl)-amine enantiomer 1 and 1-(4-(methyl-sulphonyl)phenyl)piperazine, Example 202 may be prepared as described in Example 28 (see scheme 2, step C, 2.1.3). Analytical HPLC-MS (method D): RT=1.24 min.

Workup

  1. custommay be prepared

Sources & evidence

ORD record
ord-834cdf2cc19843aaa134a38c949d839e
Source dataset
uspto-grants-2012_02
Patent number
US08114878B2

Reaction notes

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