(S)-5-dibenzylamino-1-methylpiperidin-2-one → HCID 28064098, compound

HRID 1641337Notes

Reaction equation

HRID 1641337 reaction equation
C([N:8](CC1C=CC=CC=1)[C@@H:9]1[CH2:14][N:13]([CH3:15])[C:12](=[O:16])[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][C@@H:9]1[CH2:14][N:13]([CH3:15])[C:12](=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 59708472(S)-5-dibenzylamino-1-methylpiperidin-2-one

Product 1

HCID 28064098HCID 28064098, compoundYield 101.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

450 mg (S)-5-dibenzylamino-1-methyl-piperidin-2-one are suspended in 25 ml of methanol and hydrogenated with 150 mg Pd/C 10% under a pressure of 3 bar and at a temperature of 60° C. After 16 hours the catalyst is removed by suction filtering and the filtrate is evaporated to dryness. 190 mg of the product are obtained as an oil.

Workup

  1. customAfter 16 hours the catalyst is removed by suction
  2. filtrationfiltering
  3. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-7d9338e4be754fb185965bc1f5bd6cce
Source dataset
uspto-grants-2012_02
Patent number
US08114878B2

Reaction notes

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