1,4-Dioxane hydrochloride → HCID 66735979, compound

Participants

Reaction Steps

A solution of (S)-tert-butyl-1-(5-cyclopropylpyridin-2-yl)ethylcarbamate (Method 31; 2.04 g, 7.78 mmol) in DCM (10 ml) was treated with HCl/dioxane (9.72 ml, 4 N, 38.8 mmol) and stirred at room temperature for 2 hours. The solvent was removed to give the title compound (1.73 g, 93%) as white solid. 1H NMR (400 MHz) δ 8.60 (br, 3H), 8.50 (s, 1H), 7.62 (m, 1H), 7.56 (m, 1H), 4.52 (m, 1h), 2.03 (m, 1H), 1.50 (d, J=6.8 Hz, 1H), 1.04 (m, 2H), 0.79 (m, 2H). MS: Calcd.: 162. Found: [M+H]+ 163.

Provenance & Evidence