Piperidine, 1-(2-chloroethyl)-, hydrochloride → HCID 24769550, compound

HRID 1641428Notes

Reaction equation

HRID 1641428 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[N:6]=[CH:5][CH:4]=1.Cl.Cl[CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[F:16][C:2]([F:1])([F:15])[C:3]1[N:7]([C:8]2[CH:9]=[CH:10][C:11]([O:14][CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:12][CH:13]=2)[N:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 66739088HCID 66739088, compound

Product 1

HCID 24769550HCID 24769550, compoundYield 48%

Procedure

The title compound was prepared from 4-(5-trifluoromethyl-pyrazol-1-yl)phenol (0.1 g, 0.43 mmol), 1-(2-chloroethyl)piperidine hydrochloride (0.16 g, 0.88 mmol) using the general procedure C with a yield of 48% (70 mg); 1H NMR (400 MHz, CDCl3) 7.84 (d, J=2 Hz, 1H), 7.58 (d, J=9.2 Hz, 2H), 6.98 (d, J=9.2 Hz, 2H), 6.65 (d, J=1.6 Hz, 1H), 4.14 (t, J=12, 6 Hz, 2H), 2.78 (t, J=12, 6 Hz, 2H), 2.53 (br, 4H), 1.61-1.47 (m, 6H); LC/MS (ESI): 94%.

Sources & evidence

ORD record
ord-d7b8f86a4b25454d9da372a70d59ae3f
Source dataset
uspto-grants-2012_02
Patent number
US08115005B2

Reaction notes

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