Piperidine, 1-(2-chloroethyl)-, hydrochloride → HCID 24769551, compound

HRID 1641429Notes

Reaction equation

HRID 1641429 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([F:10])([F:9])[F:8])[N:4]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)[N:3]=1.Cl.Cl[CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([F:8])([F:10])[F:9])[N:4]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)=[CH:13][CH:12]=2)[N:3]=1

Participants

3

Reactant 2

HCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 66738948HCID 66738948, compound

Product 1

HCID 24769551HCID 24769551, compoundYield 55%

Procedure

The title compound was prepared from 4-(3-Methyl-5-trifluoromethyl-pyrazol-1-yl)-phenol (0.1 g, 0.42 mmol) and 1-(2-chloroethyl)piperidine hydrochloride (0.16 g, 0.88 mmol) using the general procedure C with a yield of 55% (80 mg); 1H NMR (400 MHz, CDCl3) 7.33 (d, J=9.2 Hz, 2H), 6.98 (d, J=9.2 Hz, 2H), 6.43 (s, 1H), 4.15 (t, J=12, 6 Hz, 2H), 2.78 (t, J=12, 6 Hz, 2H), 2.53 (br, 4H), 1.61-1.47 (m, 6H); LC/MS (ESI): 94%.

Sources & evidence

ORD record
ord-a5023960ca4b41e8b0c54c8407b0b51f
Source dataset
uspto-grants-2012_02
Patent number
US08115005B2

Reaction notes

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