Boron tribromide → HCID 59660697, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-[1,3]dioxolan-2-yl-1-(4-methoxy-phenyl)-5-methyl-1H-pyrazole (0.2 g, 0.8 mmol) in CH2Cl2 (4 mL) was added boron tribromide (1M in DCM, 2.3 mL, 2.3 mmol) at −78° C. over 5 min. The reaction mixture was stirred at −78° C. for 1 h, and then at room temperature for 4 h. The reaction was quenched with sat. NaHCO3 at 0° C., extracted with CH2Cl2, washed brine, and dried over Na2SO4. After concentrated in vacuo, the title compound was obtained with a yield of 97% (150 mg), which was used to the next step without further purifications; MS (APCI) m/z: 203 (M+1, 100).

Provenance & Evidence