Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 14803011, compound

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Reaction Conditions

Reaction Steps

A mixture of tetrahydro-2H-pyran-2-yl 2,3,4,6-tetra-O-benzyl-5-thio-D-glucopyranose (3.30 g, 5.15 mmoL), pyridinium p-toluenesulfonate (518 mg, 2.06 mmoL) and ethanol (58 mL) was stirred at 80° C. for 2 hours. The reaction mixture was cooled to room temperature and the solvent was concentrated. The resulting residue was dissolved in ethyl acetate. This solution was washed with saturated aqueous sodium bicarbonate and saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. After filtering off the desiccant, the residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1) to give the titled compound (2.89 g, quant.) as a colorless crystal.

Provenance & Evidence