反应详情

温度

60 °C

To a solution of diethyl 2-[2-(4-bromophenyl)ethyl]-2-methylmalonate (55.0 g) of Reference Example 24 in ethanol (300 mL) was added potassium hydroxide (85%, 12.2 g), and the mixture was stirred at 60° C. for 5 hr. The solvent was evaporated under reduced pressure, water was added, and the aqueous layer was washed with ether. The aqueous layer was acidified with hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound (50.8 g) as a colorless oil.

1. customThe solvent was evaporated under reduced pressure, water
2. additionwas added
3. washthe aqueous layer was washed with ether
4. extractionthe mixture was extracted with ethyl acetate
5. washThe organic layer was washed with saturated brine
6. dry with materialdried over anhydrous magnesium sulfate
7. customThe solvent was evaporated under reduced pressure