Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Thiocresol | HCID 7930 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | HCID 66736357 | HCID 66736357 | — |
| Catalyst | Palladium, tris[mu-[(1,2-eta:4,5-eta)-(1E,4E)-1,5-diphenyl-1,4-pentadien-3-one]]di-, compd. with trichloromethane (1:1) | HCID 11029508 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 66736615 | HCID 66736615 | 65.4% |
Reaction Steps
A solution of 4-[2-(4′-bromo-2′-fluorobiphenyl-4-yl)ethyl]-4-di(tert-butyl)phosphoryloxymethyl-2-methyl-2-oxazoline (210 mg) of Example 23, (23-2), 3-methylbenzenethiol (49 mg), diisopropylethylamine (93 mg), tris(dibenzylideneacetone)dipalladium(0) chloroform adduct (18.6 mg) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos) (21.4 mg) in 1,4-dioxane (2 mL) was heated under reflux for 9 hr under a nitrogen atmosphere. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography to give the title compound (148 mg) as a pale-yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08114902B2 |
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| Source dataset | uspto-grants-2012_02 |
|---|
| ORD ID | ord-182952065fae45e9b064112a8ee4e9ee |
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| Source note | uspto-grants-2012_02 |
|---|
