Chlorobenzene → HCID 12383333, compound

Participants

Reaction Steps

Palladium acetate (5.6 mg, 0.025 mmol), 3-phenylbenzoic acid (99 mg, 0.5 mmol) and 4-chlorobenzene (169 mg, 1.5 mmol), butyldi-1-adamantylphosphine (19.2 mg, 0.05 mmol), Cs2CO3 (358 mg, 1.1 mmol), molecular sieves 3 Å (155 mg) and anhydrous DMF (2.5 mL). After flash chromatography and preparative HPLC 97 mg (71%) of a white solid was obtained. Analytical data are consistent with that of previously reported data.6 1H NMR (300 MHz, CDCl3) δ 7.36-7.50 (m, 10H), 7.63-7.66 (m, 2H), 7.75-7.78 (m, 1H), 8.15-8.18 (m, 1H). Carboxylate proton signal was not observed. The 1H NMR spectrum is shown in FIG. 43.

Provenance & Evidence