4-Methylpyrazole → HCID 131729448, compound

Participants

Reaction Steps

The title compound is prepared by an analogous procedure to 1R,2S,3R,5S)-3-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-5-(4-methyl-pyrazol-1-yl)-cyclopentane-1,2-diol (Intermediate BA1) by replacing Carbonic acid (1S,4R)-4-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-cyclopent-2-enyl ester ethyl ester (Intermediate AA) in step 1 with Carbonic acid (1S,4R)-4-(6-{[bis-(4-methoxy-phenyl)-methyl]-amino}-2-chloro-purin-9-yl)-cyclopent-2-enyl ester ethyl ester (Intermediate AB) and by replacing 4-methylpyrazole with 4-(tert-Butyl-diphenyl-silanyloxymethyl)-1H-pyrazole. 1H nmr (CDCl3, 400 MHz); 7.70 (m, 4H), 7.50-7.20 (m, 13H), 6.85 (m, 4H), 6.60 (s, 1H), 5.60 (s, 1H), 4.80 (m, 1H), 4.70 (m, 4H), 4.30 (m, 1H), 3.80 (s, 6H), 3.00 (m, 1H), 2.70 (m, 1H), 1.10 (s, 9H).

Provenance & Evidence