4-Aminopyridine → Carbamic acid, 4-pyridinyl-, phenyl ester

Participants

Reaction Steps

4-Amino pyridine (500 mg, 5.3 mmol) and N,N-diisopropylethylamine (685 mg, 5.3 mmol) are dissolved in dichloromethane (5 ml). Phenyl chloroformate (830 mg, 5.3 mmol) is added to the reaction mixture. The reaction mixture is stirred at room temperature for 72 hours. The reaction mixture is partitioned between dichloromethane and saturated NaHCO3 (aq). The aqueous is washed with dichloromethane (×2). The organics are combined, dried (MgSO4), filtered and reduced in vacuo to give the title compound.

Provenance & Evidence