HCID 11663413, compound → HCID 11575210, compound

HRID 1641906Notes

Reaction equation

[NH2:1][C:2]1[N:10]=[C:9]([NH:11][C@H:12]2[CH2:16][CH2:15][CH2:14][C@@H:13]2[O:17]CC2C=CC=CC=2)[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:25]1[CH2:29][C@H:28]([N:30]2[CH:34]=[C:33]([CH3:35])[CH:32]=[N:31]2)[C@@H:27]([OH:36])[C@H:26]1[OH:37].FC(F)(F)C(O)=O.NC1N=C(N[C@@H]2CCC[C@H]2O)N=C2C=1N=CN2[C@@H]1C[C@H](N2C=C(C)C=N2)[C@@H](O)[C@H]1O>>[NH2:1][C:2]1[N:10]=[C:9]([NH:11][C@H:12]2[CH2:16][CH2:15][CH2:14][C@@H:13]2[OH:17])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:25]1[CH2:29][C@H:28]([N:30]2[CH:34]=[C:33]([CH3:35])[CH:32]=[N:31]2)[C@@H:27]([OH:36])[C@H:26]1[OH:37]

Participants

Reactant 2

HCID 11663413HCID 11663413, compound

HCID 66735613HCID 66735613, compound

Product 1

HCID 11575210HCID 11575210, compound

Procedure

The title compound is prepared from (1R,2S,3R,5S)-3-[6-Amino-2-((1S,2S)-2-benzyloxy-cyclopentylamino)-purin-9-yl]-5-(4-methyl-pyrazol-1-yl)-cyclopentane-1,2-diol (Example 23) using a procedure analogous to that of (1R,2S,3R,5S)-3-[6-Amino-2-((1R,2R)-2-hydroxy-cyclopentylamino)-purin-9-yl]-5-(4-methyl-pyrazol-1-yl)-cyclopentane-1,2-diol trifluoroacetate (Example 29). MS (ES+) m/e 415 (MH+).

Sources & evidence

ORD record: ord-f15b86f2148e44e2af8a9fa898d8ee7e
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08114877B2

Reaction notes

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