Methanesulfonyl chloride → HCID 11678992, compound

HRID 1641907Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][NH:4][C:5]1[N:13]=[C:12]2[C:8]([N:9]=[CH:10][N:11]2[C@@H:14]2[CH2:18][C@H:17]([N:19]3[CH:23]=[C:22]([CH3:24])[CH:21]=[N:20]3)[C@@H:16]([OH:25])[C@H:15]2[OH:26])=[C:7]([NH:27][CH2:28][CH:29]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[N:6]=1.[S:42](Cl)([CH3:45])(=[O:44])=[O:43]>>[OH:26][C@@H:15]1[C@H:16]([OH:25])[C@@H:17]([N:19]2[CH:23]=[C:22]([CH3:24])[CH:21]=[N:20]2)[CH2:18][C@H:14]1[N:11]1[CH:10]=[N:9][C:8]2[C:12]1=[N:13][C:5]([NH:4][CH2:3][CH2:2][NH:1][S:42]([CH3:45])(=[O:44])=[O:43])=[N:6][C:7]=2[NH:27][CH2:28][CH:29]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 66735884HCID 66735884, compound

Product 1

HCID 11678992HCID 11678992, compound

Procedure

The title compound is prepared from (1R,2S,3R,5S)-3-[2-(2-Amino-ethylamino)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-5-(4-methyl-pyrazol-1-yl)-cyclopentane-1,2-diol and mesyl chloride using a procedure analogous to that of Example 31. MS (ES+) m/e 632 (MH+).

Sources & evidence

ORD record: ord-1cd28a5c7d254436a08af479e2c562bf
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08114877B2

Reaction notes

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