Trifluoroacetic acid → HCID 86622809, compound

Participants

Reaction Steps

(1R,2S,3R,5S)-3-(6-{[Bis-(4-methoxy-phenyl)-methyl]-amino}-2-chloro-purin-9-yl)-5-(4-methyl-pyrazol-1-yl)-cyclopentane-1,2-diol (Intermediate BB1) (0.020 g, 35 μmol) is dissolved in TFA (200 μL). The reaction mixture is stirred at room temperature. The reaction is shown to be complete by LCMS after 2 hours. The solvent is removed in vacuo and the title compound is obtained after purification by reverse phase column chromatography (Isolute™ C18, 0-100% acetonitrile in water—0.1% TFA). 1H nmr (MeOD, 400 MHz); 8.50 (s, 1H), 7.85 (s, 1H), 7.55 (s, 1H), 4.95 (m, 1H), 4.70 (m, 1H), 4.65 (m, 1H), 4.30 (m, 1H), 2.95 (m, 1H), 2.65 (m, 1H), 2.15 (s, 3H), MS (ES+) m/e 350 (MH+).

Provenance & Evidence