HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2-methylpropanoyl chloride hydrochloride → HCID 86622830, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2-methylpropanoyl chloride hydrochloride | HCID 21415505 | — |
| Reactant | 9-[(1R,2S,3R,4S)-2,3-dihydroxy-4-(4-hydroxymethyl-pyrazol-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purine-2-carboxylic acid (4-amino-cyclohexyl)-amide trifluoroacetate | HCID 86622821 | — |
| Reactant | HCID 86622824 | HCID 86622824 | — |
| Product | HCID 86622830 | HCID 86622830 | — |
Reaction Steps
This compound is prepared from 9-[(1R,2S,3R,4S)-2,3-dihydroxy-4-(4-hydroxymethyl-pyrazol-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purine-2-carboxylic acid (4-amino-cyclohexyl)-amide trifluoroacetate (Example 83, first step a) using a procedure analogous to that of 9-[(1R,2S,3R,4S)-2,3-dihydroxy-4-(4-hydroxymethyl-pyrazol-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purine-2-carboxylic acid [3-(3-ethyl-ureido)-propyl]-amide trifluoroacetate (Example 87) replacing ethyl isocyanate with dimethyl-amino-acetyl chloride hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08114877B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-abf68fcd0ae641ec944e38255f869c14 |
| Source note | uspto-grants-2012_02 |