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HRID1641933

反应详情

EQUATION

反应方程式

HRID 1641933 的结构方程式

REACTANTS

反应物

3
结构：CN(C)[C@@H]1CCNC1
HCID2758521

(R)-3-Dimethylaminopyrrolidine

C6H14N2

结构：O=C(O)C(F)(F)F.OCc1cnn([C@H]2C[C@@H](n3cnc4c(NCC(c5ccccc5)c5ccccc5)nc(NCCN5CCCCC5)nc43)[C@H](O)[C@@H]2O)c1
HCID66735860

未命名化合物

结构：OCc1cnn([C@H]2C[C@@H](n3cnc4c(NCC(c5ccccc5)c5ccccc5)nc(Cl)nc43)[C@H](O)[C@@H]2O)c1
HCID86622808

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)[C@@H]1CCN(c2nc(NCC(c3ccccc3)c3ccccc3)c3ncn([C@@H]4C[C@H](n5cc(CO)cn5)[C@@H](O)[C@H]4O)c3n2)C1
HCID11505482

未命名化合物

PROCEDURE

实验过程

This compound is prepared from (1R,2S,3R,5S)-3-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-5-(4-hydroxymethyl-pyrazol-1-yl)-cyclopentane-1,2-diol (BA7) using a procedure analogous to that of (1R,2S,3R,5S)-3-[6-(2,2-diphenyl-ethylamino)-2-(2-piperidin-1-yl-ethylamino)-purin-9-yl]-5-(4-hydroxymethyl-pyrazol-1-yl)-cyclopentane-1,2-diol trifluoro-acetate (Example 46) replacing 1-(2-amino-ethyl)piperidine with (3R)-(+)-3-(dimethylamino)-pyrrolidine. After purification, the compound is partitioned between DCM and saturated NaHCO3(aq). The organics are dried (MgSO4), filtered and reduced in vacuo to yield the title compound. MS (ES+) m/e 624 (MH+).

WORKUP

后处理

  1. customAfter purification
  2. customthe compound is partitioned between DCM and saturated NaHCO3(aq)
  3. dry with materialThe organics are dried (MgSO4)
  4. filtrationfiltered