Hydrochloric Acid → HCID 57544313, compound

Participants

Reaction Conditions

Reaction Steps

10.8 kg of compound (II) with R=═CH3, methyl 3-(2-oxocyclopentyl)-2-phenylacetylaminopropionate, 23.7 l of water and 5.5 kg of sodium hydroxide solution (33%) were introduced into a tank. The reaction mixture was heated to 45° C. and stirred at this temperature for 5 hours. It was cooled to 20° C., and the pH was adjusted at this temperature to pH 6.4 with hydrochloric acid (30%). The reaction mixture was diluted with 301 of water. The compound 3-(2-oxocyclopentyl)-2-phenylacetylamino-propionic acid (III) which was produced in the reaction and was in the form of a mixture of 2 diastereomeric racemates was processed further as aqueous solution in the following step without further purification.

Provenance & Evidence