反应详情

A solution of methyl 3,5-dimethyl-4-hydroxybenzoate (2.146 g) in pyridine (20 mL) was cooled in an ice-bath under a nitrogen atmosphere. Acetic anhydride (5 mL) was added drop wise and after 30 minutes at 0° C., the reaction was warmed to room temperature and stirred for 2-3 hours. The solvent was then removed under reduced pressure and the crude product was dissolved in ethyl acetate (50 mL). This solution was washed with 1 N HCl, water and brine. It was then dried over anhydrous magnesium sulfate, filtered and evaporated to dryness. Yield=2.4 g, white powder.

1. customThe solvent was then removed under reduced pressure
2. dissolutionthe crude product was dissolved in ethyl acetate (50 mL)
3. washThis solution was washed with 1 N HCl, water and brine
4. dry with materialIt was then dried over anhydrous magnesium sulfate
5. filtrationfiltered
6. customevaporated to dryness