Pentafluorophenol → 5-Oxo-pyrrolidine-3-carboxylic acid pentafluorophenyl ester

Participants

Reaction Steps

To a suspension of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDCI (1.5 mmol) in 8 mL ethyl acetate was added pentafluorophenol (3 mmol) at 0° C. After 10 minutes, 5-oxo-pyrrolidine-3-carboxylic acid VI (1 mmol) was added at 0° C. and the reaction mixture was stirred for 1 hour at room temperature. After evaporation of the solvent, the crude product was purified by chromatography on silica gel (ethyl acetate:hexane=1:2) to yield the corresponding 5-oxo-pyrrolidine-3-carboxylic acid pentafluorophenyl ester VII as a colourless oil.

Provenance & Evidence