HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1642055Generated: October 31, 2026
Bromoacetyl bromide → 2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide
https://huagongshe.com/reaction/1642055
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromoacetyl bromide | HCID 61147 | — |
| Reactant | (2-Amino-5-bromophenyl)(2-fluorophenyl)methanone | HCID 73865 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide | HCID 53440676 | — |
Reaction Steps
A mixture of (2-amino-5-bromophenyl)(2-fluorophenyl)methanone (15 g, 51.0 mmol) and sodium bicarbonate (12.85 g, 153 mmol) in CHCl3 (150 mL) was cooled in an ice bath to 0° C. A solution of 2-bromoacetyl bromide (4.89 mL, 56.1 mmol) was added drop-wise slowly and washed in with CHCl3 (30 ml). The cooling was removed and the mixture was stirred for 2 hr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08119629B2 |
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| Source dataset | uspto-grants-2012_02 |
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| ORD ID | ord-2514bf1ffb9e4acfb7778f7ff514ac38 |
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| Source note | uspto-grants-2012_02 |
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