HRID1642063

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID85247

Silane, iodotrimethyl-

C3H9ISi

结构：CCCCCCCCOc1ccc(-c2ccc(C(=O)Nc3ccccc3CP(=O)(OCC)OCC)cc2)cc1

HCID86638333

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCOc1ccc(-c2ccc(C(=O)Nc3ccccc3CP(=O)(O)O)cc2)cc1

HCID24824095

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID14798

Sodium Hydroxide

HNaO

PROCEDURE

实验过程

{2-[(4′-Octyloxy-biphenyl-4-carbonyl)-amino]-benzyl}-phosphonic acid diethylester is dissolved in CH2Cl2 and and the mixture obtained is treated with trimethylsilyl iodide at 0°. The mixture obtained is stirred at 0° for several hours and diluted with toluene. From the mixture obtained solvent is evaporated. The evaporation residue obtained is dissolved in 1N NaOH solution, washed with EtOAc, HCl is added, precipitation occurs and the precipitate obtained is collected. {2-[(4′-Octyloxy-biphenyl-4-carbonyl)-amino]-benzyl}-phosphonic acid is obtained.

WORKUP

后处理

customthe mixture obtained
customThe mixture obtained
customFrom the mixture obtained solvent
customis evaporated
customThe evaporation residue obtained
washwashed with EtOAc, HCl
additionis added
customprecipitation
customthe precipitate obtained
customis collected

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f5e0ed5eecc64310a2d55969935066ad
来源数据集: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08119617B2
来源说明: uspto-grants-2012_02

反应 SMILES

C([O:3][P:4]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])=[CH:27][CH:26]=2)=[CH:21][CH:20]=1)=[O:18])(=[O:8])[O:5]CC)C.C[Si](I)(C)C>C(Cl)Cl.C1(C)C=CC=CC=1.[OH-].[Na+]>[CH2:32]([O:31][C:28]1[CH:27]=[CH:26][C:25]([C:22]2[CH:23]=[CH:24][C:19]([C:17]([NH:16][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[CH2:9][P:4](=[O:3])([OH:8])[OH:5])=[O:18])=[CH:20][CH:21]=2)=[CH:30][CH:29]=1)[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39]