Dabco → HCID 24823497, compound

Participants

Reaction Steps

A solution of (difluoro-{3-[methyl-(4′-octyloxy-biphenyl-4-carbonyl)-amino]-phenyl}-methyl)-phosphonic acid diethyl ester (compound of example 59 in TABLE 2 below) and aproximately 3 to 5 equivalents of DABCO in acetonitrile solution is heated to 150° C. in a microwave reactor for less then 40 minutes. The mixture obtained is partitioned between EtOAc and 1N aqueous HCl. From the mixture obtained the organic phase is separated, washed with 1N aqueous HCl, and evaporated to dryness. (Difluoro-{3-[methyl-(4′-octyloxy-biphenyl-4-carbonyl)-amino]-phenyl}-methyl)-phosphonic acid monoethyl ester is obtained.

Provenance & Evidence