HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → {2-[(4'-Octyloxy-biphenyl-4-carbonyl)-amino]-phenyl}-phosphonic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-(4-Octyloxyphenyl)benzoyl chloride | HCID 11078473 | — |
| Reactant | Diethyl (2-aminophenyl)phosphonate | HCID 12482984 | — |
| Reactant | Sodium bicarbonate ethyl acetate | HCID 86584982 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | {2-[(4'-Octyloxy-biphenyl-4-carbonyl)-amino]-phenyl}-phosphonic acid diethyl ester | HCID 24824666 | — |
Reaction Steps
At rt, to a solution of (2-Amino-phenyl)-phosphonic acid diethyl ester in EtOAc are added 10 equivaltents of pyridine followed by 1 equivalent of 4′-octyloxy-biphenyl-4-carbonylchloride (VAW132) and the mixture obtained is stirred for ca. 25 minutes. The mixture obtained is subjected to an aqueous work-up (NaHCO3/EtOAc), the organic phase obtained is dried, solvent is evaporated and the evaporation residue is subjected to column chromatography. {2-[(4′-Octyloxy-biphenyl-4-carbonyl)-amino]-phenyl}-phosphonic acid diethyl ester is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119617B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-f43e521e39eb47a599501bdc2b52bd3d |
| Source note | uspto-grants-2012_02 |